A DOS based setup utility comes with the cards. The way I set up the adapters is to temporarily boot the Linux machine from a DOS floppy, and then run the configuration program on the config floppy. Using this, I set up the Interrupt line to IRQ 15 (unused for anything else in my systems) and select the media type.
If you don't already have NE2000 support in your kernel, you'll need to go to /usr/src/linux, and do a make config. Answer YES to the NE2000 support question, and you should be all set. Make sure you read the README files in /usr/src/linux after yuo build your kernel and before you reboot or else you'll waste some time getting your system to boot again. This isn't related to the Ethernet card, it's just a general tip so you don't do what I did once. It's actually not a bad idea to put new kernels onto a floppy first, and boot it from there. If it doesn't work, you just pop the floppy and reboot and you're back where you were.
If you are running an older Linux kernel, such as 1.2.13 Read instructions for older Linux kernels for additional information.
Someone else apparently has done such testing, as I've seen this card listed in the Linux Hardware Compatability HOWTO.